Each player has a board on which he will build his city. At the start of the campaign it has a few different features - empty fields, rocks, trees, and so on. The buildings he builds are represented by polyominoes, the Tetris-like shapes, in three different colors. There is a pile of cards between the players and a card with one of the polyominoes is turned over. Players must then build it in their city.

The campaign consists of 24 games, divided into 8 chapters of 3 games each. During each game, players customize their experience by adding items and rules to their personal boards and cards, and to the game. Player choices and actions made during a game carry over to the next session, creating a unique, personalized gaming experience.

The winner of each game earns development points for the campaign. As the campaign progresses, other ways to earn Development Points will be added. There are usually rule changes between games, but they are only revealed after each chapter (i.e. every third game).

For players who don't want to experience My City as a legacy game, there is an 'eternal' game on the back of the board, which can be played at any time. This game board offers an alternative setup for repeatable play. Each game is easy enough to replace players and they wouldn't be at a major disadvantage.